Dose-Dependent Clozapine-Induced Eosinophilia: A Case Report of an Unusual Adverse Drug Reaction

Abstract

Clozapine is the only antipsychotic which is effective in ‘Treatment–Resistant Schizophrenia’. However, it is associated with many side effects. Among those, eosinophilia is considered to be a non-dose dependent adverse drug reaction. We present here a case of a dose-dependent severe eosinophilia following clozapine therapy. In spite of extensive search of PubMed and Medline database we could not find any previous report of clozapine induced dose-dependent eosinophilia in the English language literature.